Dementia Prevention

You are aware of the curse of dementia [mainly as Alzheimer’s Disease – AD] either as a risk of ageing or more powerfully because of personal experience of a sufferer.

There IS an inherited ie genetic component related principally to the APOE e4 gene. But lots of people who have the gene don’t get AD. The important information is not whether you have the gene [so don’t rush to get a test] but whether the gene is switched on - this is called gene expression.

Reducing Cardiovascular Risk – Statins

Maximum prevention of cardiovascular disease [CVD] – the safety and usefulness of statins

This matters because CVD is a major killer: both cardiovascular death or hospitalisation [Major Adverse Cardiovascular Events = MACE] are almost entirely preventable by lowering blood pressure <120/80, avoiding smoking, and reducing apolipoprotein B concentration [ApoB-‘bad cholesterol’ most of which is LDL-C – this being what is usually measured]. Few if any of you will be smokers in 2023, but many of you have non-optimal BP [see previous InfoSheet on this] and less than perfect cholesterol patterns.

Reducing Cardiovascular Risk – Blood pressure

Focus on… Self-Management

A normal blood pressure [BP] is 120/80 such as you would have in your 30’s.

This matters because …

BP is a silent killer; you can’t tell from how you feel whether your BP is normal or dangerously sky-high. Raised BP is part of the metabolic syndrome [insulin resistance + raised BP + abnormal cholesterol pattern + prediabetic change] associated with mid-abdominal weight gain and major cause of cardiovascular risk [heart attack and stroke].

It’s a Bug’s Life: offer love and take care of your microbiome

You have more bacteria about you - on your skin, in your gut and all the other nooks and crannies – than there are actual human cells in your body. More importantly they do stuff that matters. Whether that is for good, or evil depends on which bacteria are in your particular crowd. This matters for the critical aims we have in respect of longevity. The goal in its simplest terms is reduce inflammaging and prevent dementia, mainly Alzheimer’s Disease [AD]. But apart from the relationship between the mouth microbiome and AD the inflammation associated with a bad microbiome in the gut triggers AD, heart disease, atopic conditions such as asthma, eczema and rhinitis, irritable bowel, inflammatory bowel disease and is a contributing cause for obesity.

Inflammation and CVD

Everyone understands that there is a  connection between ‘cholesterol’ and cardiovascular disease (CVD) and that it is the pattern of all the blood ‘lipoproteins’ not just the total cholesterol that determines the risk. 

Some of us have been mislead into thinking that dietary fat intake increases cholesterol. In fact most of our cholesterol is manufactured in the liver not eaten and eating good fats is beneficial. Abnormal blood lipids are a sign, mainly, of disordered carbohydrate metabolism and the dietary requirement is limiting sugar and refined carbohydrate intake.